| Model | Pro WS W680-ACE |
| CPU | Intel® Socket LGA1700 for 13th Gen Intel® Core™ Processors & 12th Gen Intel® Core™ |
| Chipset | Intel® W680 Chipset |
| Memory | 4 x DIMM, Max. 192GB, DDR5 ECC and Non-ECC Un-buffered Memory |
| Dual Channel Memory Architecture | |
| Supports Intel® Extreme Memory Profile (XMP) | |
| OptiMem II | |
| Graphics | 1 x DisplayPort, 1 x HDMI port, 1 x VGA port |
| (Graphics specifications may vary between CPU types) | |
| Expansion Slots | Intel® 13th & 12th Gen Processors: |
| - 2 x PCIe 5.0 x16 slots (support x16 or x8 / x8 mode) | |
| Intel® W680 Chipset: | |
| - 2 x PCIe 3.0 x16 slots (supports x4 mode) | |
| - 1 x PCIe 3.0 x1 slot | |
| Storage | Total supports 3 x M.2 slots and 8 x SATA 6Gb/s ports |
| (Intel® 13th & 12th Gen Processors and Intel® W680 Chipset) | |
| Ethernet | 2 x Intel® 2.5Gb Ethernet |
| Wireless & Bluetooth | M.2 slot only (Key E, CNVi & PCIe) (Wi-Fi module is sold separately) |
| USB | Rear USB (Total 8 ports): |
| - 2 x USB 3.2 Gen 2 ports (1 x Type-A, 1 x Type-C) | |
| - 4 x USB 3.2 Gen 1 ports (4 x Type-A) | |
| - 2 x USB 2.0 ports (2 x Type-A) | |
| Audio | Realtek 7.1 Surround Sound High Definition Audio CODEC |
| - Supports: Jack-detection, Multi-streaming, Front Panel Jack-retasking | |
| - Supports up to 24-Bit/192 kHz playback | |
| Back Panel I/O Ports | Various USB ports, DisplayPort, HDMI, VGA, Ethernet, Audio jacks, BIOS FlashbackTM button |
| Internal I/O Connectors | Headers for fans, power, storage, USB, and more |
| Special Features | ASUS 5X PROTECTION III, ASUS Q-Design, ASUS Thermal Solution, ASUS EZ DIY |
| BIOS | 256 Mb Flash ROM, UEFI AMI BIOS |
| Manageability | WOL by PME, PXE |
| Accessories | Cables, Q-connector, Screw packages, I/O Shield, User guide, ACC Express Activation Key Card |
| Operating System | Windows® 11, Windows® 10 64-bit |
| Form Factor | ATX Form Factor (12 inch x 9.6 inch) |